Publications in the last years

To learn more about our background and expertise, here you have detailed information about the publications of the last years. You can find more about our research here and here.

2024

Navarro E & Esteras N. Multitarget effects of Nrf2 signalling in the brain: common and specific functions in different cell types Antioxidants. 13(12): 1502 (2024).

Rodríguez-Carreiro S, Nogales M, Jiménez-Galán D, Carmona-Lorenzo S, Caro-Martín A, Navarro E, Esteras N. Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration Regen Med Rep. 1: 31-51 (2024).

Navarro, E.; Esteras, N. A new mutation in the Parkinson’s-related FBXO7 gene impairs mitochondrial and proteasomal function Febs j, 291 (12), 2562-2564 (2024).

Navarro, E.; Efthymiou, A. G.; Parks, M.; Riboldi, G. M.; Vialle, R. A.; Udine, E.; Muller, B. Z.; Humphrey, J.; Allan, A.; Argyrou, C. C.; et al. LRRK2 G2019S variant is associated with transcriptional changes in Parkinson’s disease human myeloid cells under proinflammatory environment bioRxiv (2024).

de Talhouët, C.; Esteras, N.; Soutar, M. P. M.; O’Callaghan, B.; Plun-Favreau, H. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy Sci Rep, 14 (1), 11721 (2024).

Choya-Foces, C.; Navarro, E.; Ríos, C. L.; López, M. G.; Egea, J.; Hernansanz-Agustín, P.; Martínez-Ruiz, A. The mitochondrial Na(+)/Ca(2+) exchanger NCLX is implied in the activation of hypoxia-inducible factors Redox Biol, 77, 103364 (2024).

Theparambil, S. M.; Kopach, O.; Braga, A.; Nizari, S.; Hosford, P. S.; Sagi-Kiss, V.; Hadjihambi, A.; Konstantinou, C.; Esteras, N.; Gutierrez Del Arroyo, A.; et al. Adenosine signalling to astrocytes coordinates brain metabolism and function Nature, 632 (8023), 139-146 (2024).

Vinokurov, A. Y.; Palalov, A. A.; Kritskaya, K. A.; Demyanenko, S. V.; Garbuz, D. G.; Evgen’ev, M. B.; Esteras, N.; Abramov, A. Y. Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease Mol Neurobiol, 61 (10), 7785-7795 (2024).

2023

Rodríguez-Carreiro, S.; Navarro, E.; Muñoz, E.; Fernández-Ruiz, J. The Cannabigerol Derivative VCE-003.2 Exerts Therapeutic Effects in 6-Hydroxydopamine-Lesioned Mice: Comparison with The Classic Dopaminergic Replacement Therapy Brain Sci, 13 (9) (2023).

Humphrey, J.; Brophy, E.; Kosoy, R.; Zeng, B.; Coccia, E.; Mattei, D.; Ravi, A.; Efthymiou, A. G.; Navarro, E.; Muller, B. Z.; et al. Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing medRxiv (2023).

Gómez-Cañas, M.; Rodríguez-Cueto, C.; Satta, V.; Hernández-Fisac, I.; Navarro, E.; Fernández-Ruiz, J. Endocannabinoid-Binding Receptors as Drug Targets. Methods Mol Biol 2023, 2576, 67-94 (2023)

Esteras, N.; Blacker, T. S.; Zherebtsov, E. A.; Stelmashuk, O. A.; Zhang, Y.; Wigley, W. C.; Duchen, M. R.; Dinkova-Kostova, A. T.; Abramov, A. Y. Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes Redox Biol, 62, 102672 (2023).

2022

Shevtsova, E. F.; Angelova, P. R.; Stelmashchuk, O. A.; Esteras, N.; Vasil’eva, N. A.; Maltsev, A. V.; Shevtsov, P. N.; Shaposhnikov, A. V.; Fisenko, V. P.; Bachurin, S. O.; et al. Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity Sci Rep, 12 (1), 12766 (2022).

Setó-Salvia, N.; Esteras, N.; de Silva, R.; de Pablo-Fernandez, E.; Arber, C.; Toomey, C. E.; Polke, J. M.; Morris, H. R.; Rohrer, J. D.; Abramov, A. Y.; et al. Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation J Cell Mol Med, 26 (4), 1327-1331 (2022).

Schilder, B. M.; Navarro, E.; Raj, T. Multi-omic insights into Parkinson’s Disease: From genetic associations to functional mechanisms Neurobiol Dis, 163, 105580 (2022).

Riboldi, G. M.; Vialle, R. A.; Navarro, E.; Udine, E.; de Paiva Lopes, K.; Humphrey, J.; Allan, A.; Parks, M.; Henderson, B.; Astudillo, K.; et al. Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease Mol Neurodegener, 17 (1), 52 (2022).

Lopes, K. P.; Snijders, G. J. L.; Humphrey, J.; Allan, A.; Sneeboer, M. A. M.; Navarro, E.; Schilder, B. M.; Vialle, R. A.; Parks, M.; Missall, R.; et al. Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies Nat Genet, 54 (1), 4-17 (2022).

Komilova, N. R.; Angelova, P. R.; Berezhnov, A. V.; Stelmashchuk, O. A.; Mirkhodjaev, U. Z.; Houlden, H.; Gourine, A. V.; Esteras, N.; Abramov, A. Y. Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson’s disease Febs j, 289 (3), 699-711 (2022).

Esteras, N.; Kopach, O.; Maiolino, M.; Lariccia, V.; Amoroso, S.; Qamar, S.; Wray, S.; Rusakov, D. A.; Jaganjac, M.; Abramov, A. Y. Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia Alzheimers Dement, 18 (2), 318-338 (2022).

Esteras, N.; Abramov, A. Y. Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond Free Radic Biol Med, 189, 136-153 (2022).

Choi, M. L.; Chappard, A.; Singh, B. P.; Maclachlan, C.; Rodrigues, M.; Fedotova, E. I.; Berezhnov, A. V.; De, S.; Peddie, C. J.; Athauda, D. […] Esteras N […]; et al. Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity Nat Neurosci, 25 (9), 1134-1148 (2022).

2021

Navarro, E.; Udine, E.; Lopes, K. P.; Parks, M.; Riboldi, G.; Schilder, B. M.; Humphrey, J.; Snijders, G. J. L.; Vialle, R. A.; Zhuang, M.; et al. Dysregulation of mitochondrial and proteolysosomal genes in Parkinson’s disease myeloid cells Nat Aging, 1 (9), 850-863 (2021).

Navarro, E.; Norden, D. M.; Trojanowski, P. J.; Godbout, J. P.; López, M. G. [Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals[(https://pmc.ncbi.nlm.nih.gov/articles/PMC8067582/) Molecules, 26 (8) (2021).

Kopach, O.; Esteras, N.; Wray, S.; Abramov, A. Y.; Rusakov, D. A. Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia Cell Death Dis, 12 (8), 716 (2021).

Kamynina, A.; Esteras, N.; Koroev, D. O.; Angelova, P. R.; Volpina, O. M.; Abramov, A. Y. Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons J Cell Physiol, 236 (9), 6496-6506 (2021).

Esteras, N.; Kundel, F.; Amodeo, G. F.; Pavlov, E. V.; Klenerman, D.; Abramov, A. Y. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase Febs j, 288 (1), 127-141 (2021).

Cheng, X.; Vinokurov, A. Y.; Zherebtsov, E. A.; Stelmashchuk, O. A.; Angelova, P. R.; Esteras, N.; Abramov, A. Y. Variability of mitochondrial energy balance across brain regions J Neurochem, 157 (4), 1234-1243 (2021).

Angelova, P. R.; Esteras, N.; Abramov, A. Y. Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention Med Res Rev, 41 (2), 770-784 (2021).

2020

Turovsky, E. A.; Braga, A.; Yu, Y.; Esteras, N.; Korsak, A.; Theparambil, S. M.; Hadjihambi, A.; Hosford, P. S.; Teschemacher, A. G.; Marina, N.; et al. Mechanosensory Signaling in Astrocytes J Neurosci, 40 (49), 9364-9371 (2020).

Ramdhani, S.; Navarro, E.; Udine, E.; Efthymiou, A. G.; Schilder, B. M.; Parks, M.; Goate, A.; Raj, T. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs PLoS Genet, 16 (2), e1008549 (2020).

Kopach, O.; Esteras, N.; Wray, S.; Rusakov, D. A.; Abramov, A. Y. Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia J Cell Sci, 133 (10) (2020).

Esteras, N.; Adjobo-Hermans, M. J. W.; Abramov, A. Y.; Koopman, W. J. H. Visualization of mitochondrial membrane potential in mammalian cells Methods Cell Biol, 155, 221-245 (2020).

Esteras, N.; Abramov, A. Y. Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology Cells, 9 (9) (2020).

Britti, E.; Ros, J.; Esteras, N.; Abramov, A. Y. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death Cell Calcium, 86, 102150 (2020).